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D6-05

SYMPTOM ATTRIBUTION AFTER MILD TRAUMATIC

BRAIN INJURY

William Panenka

, Noah Silverberg

University of British Columbia, Psychiatry, Vancouver, Canada

Over-attributing headache, fatigue, concentration difficulty and other

symptoms to mild traumatic brain injury (MTBI), instead of benign

causes such as daily stress, is thought to impede recovery. The present

study examines symptom attribution after MTBI and its correlates. The

sample consisted of highly symptomatic patients seeking treatment for

MTBI at an outpatient concussion clinic 23.9 days (SD

=

7.9) post-injury

(N

=

30; 60% female). As part of a clinical trial, a prognostic algorithm

was applied to consecutive cases and only those at high risk for chronic

symptoms were included. In the baseline assessment, participants com-

pleted the Rivermead Post Concussion Symptoms Questionnaire (RPQ)

and then rated the degree to which each symptom was caused by their

MTBI on a scale ranging from 0 (not at all) to 4 (entirely). Participants

reported a median of 13 symptoms (IQR: 9 to 15) and attributed a median

of 12 symptoms (IQR: 8 to 14) mostly or entirely to MTBI. One quarter

of the sample (26.7%, n

=

8) attributed every symptom to MTBI. Head-

aches, dizziness, nausea, slowed thinking, and double vision were vir-

tually always (

>

95%) attributed to MTBI. Sleep disturbance and

depressed mood were least often (80%) attributed to MTBI. RPQ total

scores were associated with a higher number of symptoms attributed to

MTBI (r

=

.431, p

=

.017) and a stronger degree of attribution (r

=

.873,

p

<

.001). Adjusting for symptom severity, patients who attributed every

one of their symptoms to MTBI were

less

anxious (Hospital Anxiety and

Depression Scale

=

7.48 vs. 11.33, p

=

.025, Cohen’s d

=

0.61), had sim-

ilar expectations for recovery on the Illness Perception Questionnaire-

Revised (14.09 vs. 15.60 p

=

.352, Cohen’s d

=

0.25), and were no more

likely to be litigating (

v

2

(1)

=

.29, p

=

.59). In conclusion, patients who

report more symptoms after MTBI tend to believe MTBI is the primary

cause. However, over-attributing symptoms to MTBI was not associated

with known risk factors for chronic post-concussion syndrome, and so

may not be involved in the development of this condition.

Keywords: MTBI, Symptom Attribution, Concussion, Symptom

Severity

D6-06

TEMPORAL PROFILE OF CARE FOLLOWING MILD

TRAUMATIC BRAIN INJURY: PREDICTORS TO HOSPITAL

ADMISSION, OUTPATIENT REFERRAL AND OUTCOME

John Yue

1

, Sourabh Sharma

1

, Ethan Winkler

1

, Mary Vassar

1

,

Jonathan Rick

1

, Jonathan Ratcliff

2

, Opeolu Adeoye

2

, Adam

Ferguson

1

, Hester Lingsma

3

, Frederick Korley

4

, Gabriela Satris

1

,

Caitlin Robinson

1

, Esther Yuh

1

, Pratik Mukherjee

1

, Thomas

McAllister

5

, Ramon Diaz-Arrastia

6

, Alex Valadka

7

, Wayne Gordon

8

,

David Okonkwo

9

, Geoffrey Manley

1

1

UCSF, Neurosurgery, San Francisco, USA

2

Univ. Cincinnati, Emergency Medicine, Cincinnati, USA

3

Erasmus, Public Health, Rotterdam, Netherlands

4

Johns Hopkins Univ., Emergency Medicine, Baltimore, USA

5

Univ. Indiana, Psychiatry, Indianapolis, USA

6

USUHS, Neurology, Bethesda, USA

7

Seton Brain & Spine Institute, Neurosurgery, Austin, USA

8

Mount Sinai Hospital, Rehabilitation, New York, USA

9

Univ. Pittsburgh, Neurosurgery, Pittsburgh, USA

To date, guidelines for medical follow-up after mild traumatic brain

injury (mTBI) are not defined, and better characterization of the tem-

poral relationship between hospital admission, outpatient care, and re-

covery after mTBI is needed. We utilized the TRACK-TBI Pilot study

to evaluate characteristics of mTBI patients 1) triaged to hospital ad-

mission, 2) referred to 3-month outpatient care, and 3) assessed with 6-

month functional disability (GOSE

<

7). Adult patients with GCS 13–

15, Marshall Score 1–2, without neurosurgical intervention and alive at

6-months post-injury were included. Of 168 patients (age 44.5

17.9

years, 69% male), 48% were admitted to hospital, 22% received out-

patient care, and 27% reported 6-month functional disability. In-

tracranial lesion on CT (odds ratio (OR) 81.08, 95% CI [10.28–639.36])

and post-traumatic amnesia (

>

30min-vs.-

<

30min: OR 5.27 [1.75–

15.87]; unknown-vs.-

<

30min: OR 4.43 [1.26–15.64]) predicted hos-

pital admission after adjusting for age, employment, anticoagulant use,

and prior medical history (PMH). Age (OR 1.03 [1.00–1.05]) and

employment (part-time/unemployed-vs.-full-time: OR 0.17 [0.06–0.50])

predicted 3-month outpatient referral after adjusting for gender and

PMH. Education years (OR 0.86 [0.76–0.97]), GCS

<

15 (OR 2.46

[1.05–5.78]), and PMH of seizures (OR 3.62 [1.21–10.89]) predicted

6-month functional disability after adjusting for psychiatric history. The

analysis demonstrates that while clinical factors modulate triage to

admission, PMH and socioeconomic factors modulate medical follow-

up. Underlying reasons for this divergence need further clarification for

better triage and resource allocation.

Keywords: Clinical Trial, Human Studies, Outcome, Mild TBI

D6-07

OPTIMIZING ENVIRONMENTAL ENRICHMENT TO MOD-

EL PRECLINICAL NEUROREHABILITATION

Megan J. LaPorte, Sonya Besagar, Jeffrey P. Cheng, Corina O. Bondi,

Anthony Kline

University of Pittsburgh, Department of Physical Medicine & Re-

habilitation, Pittsburgh, USA

Traumatic brain injury (TBI) affects 1.7 million people in the USA

each year. One therapeutic strategy that has been investigated is en-

vironmental enrichment (EE), which consists of a complex living

space that confers cognitive and motor recovery when provided early

and continuously after TBI vs. standard (STD) housing. Furthermore,

6-hours of EE/day introduced immediately after TBI is also sufficient

to promote neurobehavioral recovery. However, these paradigms are

not clinically ideal as patients, especially those with moderate-to-

severe TBI, will not be able to engage in rehabilitation until after

critical care has ended. Furthermore, once rehabilitation is initiated

the duration of the therapy is limited, often ranging from 3–6 hours/

day. Hence, refinement of the current model of EE such that it con-

forms more closely to that seen in real-world rehabilitation practice is

a priority in order to advance a preclinical model of rehabilitation that

can be applied to the TBI setting for implementation and assessment of

therapies. Hence, to mimic the clinic, the goal of this study was to test

the hypothesis that

delayed-and-abbreviated EE (i.e., rehabilitation)

would confer similar behavioral benefits as early-and-continuous EE.

Anesthetized male rats were subjected to a cortical impact (2.8mm

depth at 4m/s) or sham injury and randomly assigned to TBI

+

EE

(continuous), TBI

+

EE (rehabilitation; i.e., 3-day delayed, 6-hr day),

and respective sham controls. Motor function (beam-balance/beam-

walk) was assessed on post-operative days 1–5. Spatial learning/

memory (MWM) was evaluated on days 14–19. The data showed that

EE, regardless of timing, improved motor and cognitive function

compared to STD (

p

<

0.0001). Moreover, there were no differences

between TBI

+

EE (continuous) and TBI

+

EE (rehabilitation);

p

>

0.05.

These data demonstrate that delayed and abbreviated EE produces

A-111